EFFECTIVENESS OF TREATMENTS FOR CORONARY ARTERY DISEASE
DOI:
https://doi.org/10.5281/zenodo.23178887Keywords:
Myocardial infarction, biomaterials, inflammatory cardiovascular diseases, hyaluronic acidAbstract
This review is to evaluate the current evidence on the effects of biomaterials on different cell types involved in cardiac repair and regeneration following myocardial infarction. Particular attention is given to the interactions of biomaterials with cardiomyocytes, fibroblasts, endothelial cells, macrophages, cardiac progenitor cells, and mesenchymal stromal cells, as well as their effects on inflammation, angiogenesis, fibrosis, extracellular matrix remodeling, and cellular survival. A structured literature review was conducted to identify and evaluate studies investigating the effects of biomaterials on cellular processes involved in cardiac repair and regeneration following myocardial infarction. The review was designed in accordance with the principles of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) guidelines. The literature demonstrates a substantial expansion of biomaterial-based approaches for myocardial repair following myocardial infarction (MI). The biological effects of biomaterials were found to depend strongly on their composition, mechanical properties, degradation characteristics, architecture, surface chemistry, and the presence of incorporated biological signals. Biomaterials can support cardiomyocyte survival, promote endothelial cell-mediated angiogenesis, regulate macrophage-driven inflammation, modulate fibroblast activation and extracellular matrix remodeling, and improve the retention and regenerative activity of stem and mesenchymal stromal cells. These coordinated cellular effects may contribute to reduced adverse ventricular remodeling and improved structural and functional recovery of the injured myocardium.References
1. Ahmadi A., McNeill B., Vulesevic B., Kordos M., Mesana L., Thorn S., et al. (2014a). The role of integrin α2 in cell and matrix therapy that improves perfusion, viability and function of infarcted myocardium. Biomaterials 35, 4749–4758. 10.1016/j.biomaterials.2014.02.028.
2. Ahmadi A., Vulesevic B., Blackburn N. J. R., Ruel J. J. M., Suuronen E. J. (2014b). A collagen-chitosan injectable hydrogel improves cardiac remodeling in a mouse model of myocardial infarction. J. Biomater. Tissue Eng. 4, 886–894. 10.1166/jbt.2014.1264.
3. Antman E. M., Anbe D. T., Armstrong P. W., Bates E. R., Green L. A., Hand M., et al. (2004). ACC/AHA task force on practice guidelines (writing committee to revise the 1999 guidelines for the management of patients with acute myocardial infarction). ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction--executive summary: a report of the American College of Cardiology/ American Heart Association task force on practice guidelines. Circulation 10, 588–636. 10.1161/01. CIR.0000134791.68010.FA.
4. Awada H. K., Hwang M. P., Wang Y. (2016). Biomaterials towards comprehensive cardiac repair and regeneration after myocardial infarction: aspects to consider and proteins to deliver. Biomaterials 82, 94–112. 10.1016/j.biomaterials.2015.12.025.
5. Badylak S. F., Valentin J. E., Ravindra A. K., McCabe G. P., Stewart-Akers A. M. (2008). Macrophage phenotype as a determinant of biologic scaffold remodeling. Tissue Eng. Part A 14, 1835–1842. 10.1089/ ten.tea.2007.0264.
6. Baei P., Jalili-Firoozinezhad S., Rajabi-Zeleti S., Tafazzoli-Shadpour M., Baharvand H., Aghdami N. (2016). Electrically conductive gold nanoparticle-chitosan thermosensitive hydrogels for cardiac tissue engineering. Mater. Sci. Eng. C 63, 131–141. 10.1016/j.msec.2016.02.056.
7. Bayomy A. F., Bauer M., Qiu Y., Liao R. (2012). Regeneration in heart disease—Is ECM the key? Life Sci. 91, 823–827. 10.1016/j.lfs.2012.08.
8. Biernacka A., Frangogiannis N. G. (2011). Aging and cardiac fibrosis. Aging Dis. 2, 158–173. 10.1016/j. bbi.2008.05.010.
9. Blackburn N. J. R., Sofrenovic T., Kuraitis D., Ahmadi A., McNeill B., Deng C., et al. (2015). Timing underpins the benefits associated with injectable collagen biomaterial therapy for the treatment of myocardial infarction. Biomaterials 39, 182–192. 10.1016/j.biomaterials.2014.11.004.
10. Frangogiannis N., G. (2014). The inflammatory response in myocardial injury, repair, and remodelling. Nat. Rev. Cardiol, 11, 255–265. https://doi.org/10.1038/nrcardio.2014.28
11. Frangogiannis N., G. (2017). The extracellular matrix in myocardial injury, repair, and remodeling. Nat. Rev. Cardiol, 14, 611–624. https://doi.org/10.1038/nrcardio.2017.113
12. Prabhu S., D., & Frangogiannis N., G. (2016). The biological basis for cardiac repair after myocardial infarction: from inflammation to fibrosis. Circ. Res, 119, 91–112. https://doi.org/10.1161/CIRCRESAHA.116.303577
13. Rowland C., R., Hohlfeld, J., Hall S. R., R., et al. (2017). Biomaterials for cardiac tissue engineering and myocardial regeneration. Adv. Drug Deliv. Rev, 121, 1–15.
14. Liu, Z., Zheng, Z., Xie, J., Wei, H., & Yu C., Y. (2024). Hydrogel-based cardiac patches for myocardial infarction therapy: Recent advances and challenges. Mater. Today Bio. 2024;29:101331. doi:10.1016/j.mtbio.2024.101331. https://doi.org/10.1016/j.mtbio.2024.101331
15. Xu, Q., Xiao, Z., Yang, Q., et al. (2024). Hydrogel-based cardiac repair and regeneration function in the treatment of myocardial infarction. Mater. Today Bio. 2024;25:100978. doi:10.1016/j.mtbio.2024.100978. https://doi.org/10.1016/j.mtbio.2024.100978
16. Liang, J., Lv, R., Li, M., et al. (2024). Hydrogels for the treatment of myocardial infarction: design and therapeutic strategies. Macromol. Biosci. 2024;24(2). doi:10.1002/mabi.202300302.
Downloads
Published
How to Cite
Issue
Section
