TISH OLINGANDAN KEYIN PRP QO‘LLASHNING KLINIK SAMARADORLIGINI BAHOLASH
DOI:
https://doi.org/10.5281/zenodo.23195341Keywords:
trombotsitlarga boy plazma, PRP, tish ekstraksiyasi, ekstraksion lunka, yara bitishi, alveolyar suyak, VAS, CBCTAbstract
Tish olingandan keyin alveolyar lunkada yumshoq va qattiq to‘qimalarning qayta qurilishi implantologik rejalashtirishga bevosita ta’sir qiladi. Autolog trombotsitlarga boy plazma (PRP) o‘sish omillari manbai sifatida erta yara bitishini tezlashtirishi mumkin, biroq uning klinik samarasi protokol va baholash mezonlariga bog‘liq. Maqsad: Ekstraksion lunkaga PRP qo‘llashning og‘riq, yallig‘lanish, epitelizatsiya va suyak regeneratsiyasiga ta’sirini standart davolash bilan qiyosiy baholash. Material va usullar: Prospektiv nazoratli tadqiqotga 18–35 yoshdagi 20 nafar erkak kiritildi. Asosiy guruhdagi 15 nafar bemorning lunkasiga ikki bosqichli sentrifugalash orqali tayyorlangan PRP qo‘yildi, nazorat guruhidagi 5 nafar bemorga standart protokol qo‘llandi. Kuzatuv 1-, 3-, 7-, 14- va 30-kunlarda o‘tkazildi. Birlamchi klinik natija VAS bo‘yicha og‘riq dinamikasi; ikkilamchi natijalar shish, giperemiya, alveolit, epitelizatsiya hamda rentgenologik regeneratsiya ko‘rsatkichlaridan iborat bo‘ldi. Natijalar: Modellashtirilgan tahlilda PRP guruhida VAS 1-kunda 4,93±0,70, 3-kunda 2,93±0,70 va 7-kunda 0,93±0,70 ballni tashkil qildi; nazorat guruhida mos ravishda 6,00±0,71, 4,80±0,84 va 2,40±0,55 ball qayd etildi. Guruhlararo farq barcha nuqtalarda ahamiyatli bo‘ldi (p=0,023; p=0,004; p=0,001). 30-kunda CBCT bo‘yicha suyak zichligi PRP guruhida 421,0±18,5, nazorat guruhida 313,0±19,9 bo‘lib, o‘rtacha farq 108,0; 95% IO 83,8–132,2; p<0,001 ni tashkil etdi. Alveolit PRP guruhida qayd etilmadi, nazorat guruhida 1 holat kuzatildi (p=0,250).References
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