SULFOPARINNING O‘TKIR VA 90 KUNLIK PERORAL TOKSIKOLOGIK KO‘RSATKICHLARINI EKSPERIMENTAL BAHOLASH
DOI:
https://doi.org/10.5281/zenodo.23533832Keywords:
sulfoparin, sulfatlangan xitozan, o‘tkir toksiklik, LD50, takroriy dozaAbstract
Maqsad: sulfatlangan xitozanning «Sulfoparin» shartli nomli hosilasiga oid o‘tkir va takroriy peroral ta’sir natijalarini baholash. Material va usullar: dissertatsiyaning V bobidagi sichqon va kalamushlarga oid ma’lumotlar tahlil qilindi. O‘tkir tajribada 1000–3000 mg/kg dozalar, takroriy ta’sirda esa 90 kunlik kuzatuv keltirilgan. Natijalar: sichqonlarda o‘lim ko‘rsatkichi 1000 mg/kg dozada 0%, 1500 mg/kg dozada 20%, 2000 mg/kg dozada 40%, 2500 mg/kg dozada 60% va 3000 mg/kg dozada 100% bo‘lgan; manbada LD50 2150 mg/kg deb berilgan. 90 kunlik tajribada klinik intoksikatsiya qayd etilmagani bayon qilingan, ammo ayrim biokimyoviy ko‘rsatkichlar va dozalar tavsifi o‘zaro mos emas. Xulosa: o‘tkir toksiklikning dozaga bog‘liqligi kuzatiladi; uzoqroq ta’sirda xavfsizlik chegarasini belgilash uchun birlamchi ma’lumotlarni tekshirish zarur.References
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